It is presumed that Ayurvedic drugs have lesser side effects as compared to allopathic drugs. For the safety to use these plants and preparations (Oral solid dosage form, Novel drug delivery, Tropical and powder forms), the medicinal plants need to be evaluated for their toxicity. The aim of this study was to test the acute toxicity of natural materials extracted from indigenously edible fruits available in Chhattisgarh such as Diospyros melonoxylon Roxb. belonging to family Ebenaceae, commonly known as Tendu in Hindi is a small tree with rather slender stem and smooth grey bark, Buchanania lanzan spreng commonly known as Char in Hindi is a tree of 12-15 mt high, with straight trunk, belonging to family from Anacardiaceae and Manilkara zapota (Linn.) P. Royen syn., belonging to family from sapotaceae commonly known as Chiku in Hindi is a large, evergreen, forest tree more than 30 mt in height a tree belonging to family from sapotaceae. These three plants are easily available in the forests of Chhattisgarh and their various parts are used in tretment of various diseases traditionaly. The acute toxicity study was studied on Swiss mice with a dose of 2 g/Kg body weight orally. The single administration exposure of the seed powder mucilage in the form of aqueous slurry on Swiss mice was carried out and the exposure route was oral with water as a vehicle. The observations of changes in body weight, food and water intake as well as cage side observations were reported. The plants were found to be nontoxic as no mortality was recorded even at the highest dose level.
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